| Date | Location | Result | |
| Apr 20, 2022 | Winter Park, Fla. | Rollins 19, Saint Leo 11 | |
| 4/13/2022 | Lakeland, Fla. | Florida Southern 25, Saint Leo 17 | |
| 4/2/2022 | Tampa, Fla. | Tampa 20, Saint Leo 8 | |
| 4/28/2022 | Tampa, FL | Tampa 19, Saint Leo 6 | |
| 4/24/2022 | Daytona Beach, Fla. | Saint Leo 14, Embry-Riddle (FL) 12 | |
| Apr 16, 2022 | St. Leo, FL | Saint Leo 18, PBA 4 | |
| Apr 09, 2022 | St. Leo, FL | Saint Leo 10, Florida Tech 9 | |
| Mar 26, 2022 | St. Leo, FL | Saint Leo 18, LYNN(1~1 9 | |
| Mar 24, 2022 | St. Leo, FL | CMWL 13, Saint Leo 12 | |
| Mar 16, 2022 | St. Leo, FL | STA 17, Saint Leo 9 | |
| Mar 10, 2022 | St. Leo, FL | SHU-W 18, Saint Leo 10 | |
| Mar 08, 2022 | St. Leo, FL | Saint Leo 17, LEE 6 | |
| Mar 04, 2022 | St. Leo, FL | Saint Leo 12, UMOWL 8 | |
| Mar 02, 2022 | St. Leo, Fla. | ASSUMPTI 19, Saint Leo 10 | |
| Feb 25, 2022 | St. Leo, Fla. | QUWLAX22 20, Saint Leo 7 | |
| Feb 17, 2022 | St. Leo, FL | GV 18, Saint Leo 11 | |
| 2/9/2022 | Berend Field | Florida Southern 19, Saint Leo 13 | |
| Feb 11, 2022 | Saint Leo | Saint Leo 20, UAH 10 |